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The FDA does require a boxed warning for GLP-1 receptor agonists (Wegovy, Saxenda) and the dual GIP/GLP-1 receptor agonist tirzepatide (Zepbound) regarding thyroid C-cell tumors, based on rodent studies, though human relevance remains uncertain

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Additionally, GPER is involved in the -oxidation of fatty acids, enhancing the utilization of fatty acids as an energy source by tumor cells

and muscle strength, function, and quality of life did not improve, so the fat-free mass gains should be interpreted with caution, he says