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To Maintain Weight Loss Microdosing is common after patients have used higher doses of a GLP-1 to reach their target weight in order to help with weight maintenance, says Sharon Giese, MD, a New York City plastic surgeon who has been prescribing GLP-1s since 2022

I saw my percent body fat go down and my lean muscle increase, which are actually way better markers and metrics of well-being and longevity than a BMI, which often kind of gets it wrong, he says

These hormones influence appetite and metabolism, but they do not directly affect muscle growth or hormones such as testosterone or cortisol

After stopping, it takes roughly 5 half-lives (about 30 days) for the compound to clear the body