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Pfeuffer and coworkers discovered that in people with an apolipoprotein E genotype, quercetin reduces metabolic parameters, including waist circumference, postprandial blood glucose, and lipids, while increasing inflammatory markers like TNF-., IL-1, IL-10, Caspase-3, Bax/Bcl-2 (241)

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Chevrot R, Rosen R, Haudecoeur E, Cirou A, Shelp BJ, Ron E, Faure D (2006) GABA controls the level of quorum-sensing signal in Agrobacterium tumefaciens

This approach can reduce dosing requirements and help overcome certain resistance mutations