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When mitochondrial function is disrupted, they specifically interact with Parkin, acting as anchoring platforms for the recruitment of cytosolic Parkin to damaged mitochondria

Given that sensory or gastrointestinal adverse effects, such as dysgeusia and persistent nausea, can impair nutritional intake and lead to early treatment discontinuation (particularly in vulnerable populations) future research must incorporate rigorous sensory testing, larger and more diverse cohorts, and adherence-related outcomes to clarify how incretin therapies influence taste perception and long-term eating behavior (153, 157, 161)

The inflammatory state extends to the brain, contributing to conditions such as Alzheimer's disease (a neurodegenerative disorder characterized by progressive memory loss and cognitive decline)