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Two versions exist, and they behave very differently in the body

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TABLE 1 Examples of proteins that have been shown to be induced to form pores in the mitochondrial outer membrane when exposed to cardiolipin

To explain this finding, it may be noted that GltT, although required for L-glutamate transport, is highly homologous to the VacJ/Yrb ABC transport system, a proposed phospholipid transporter for maintaining lipid asymmetry in the Gram-negative outer membrane (Mla pathway) (Malinverni and Silhavy, 2009), also involved in outer membrane vesicle (OMV) formation (Roier et al., 2016)