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The article says semaglutide and tirzepatide do not substantially alter warfarin, apixaban, dabigatran, or rivaroxaban metabolism through cytochrome P450 pathways, which lowers concern about added bleeding risk during escalation

In vivo, Ex-4 has been demonstrated to inhibit prostate cancer cell growth by activating GLP-1R, reducing s-phase kinase-associated protein-2 (SKP2) gene expression, subsequently increasing p27Kip1 (p27) protein levels, and inducing tumor cell cycle arrest [67]

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Dulaglutide, another synthetic GLP-1 agonist, offers once-weekly dosing via subcutaneous injection and carries similar efficacy to semaglutide but with a slightly different side-effect profile