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Collectively, these results demonstrate that USP2 deletion, either globally or specifically in TECs, protects against UUO-induced renal fibrosis and ferroptosis, likely through regulating the ubiquitination of TFRC and TXNDC5, and possibly via its own lactylation

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In addition, a subset of subjects who were eligible (no metal in situ or reported claustrophobia) ( n = 20) underwent MRI and MRS to assess total and regional fat volumes at baseline, week nine and week 18