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HFpEF is the most common form of heart failure and a significant unmet need in cardiology with limited treatment options 22,23
The disease is characterized by progressive glandular hypoplasia, invasion of the affected lacrimal and salivary glands by CD4 + T cells, along the existence of anti-Ro/SSA antibodies in the serum [275, 276]
Animal studies showed retatrutide producing lower expression levels of inflammatory and fibrotic mediators compared to tirzepatide, suggesting the triple mechanism may offer benefits beyond additional weight loss
Many patients report significant changes in hunger levels, fullness cues, and even food preferences
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