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Melanotan II produces melanogenesis by activation of the MC1 receptor , whereas its clinically documented sexual effects are thought to be related to its ability to activate the MC4 receptor (though the MC3 is thought to also possibly be involved)

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Intriguingly, this fibrotic condition, characterised by enlarged raised scars that spread beyond the limits of the original wound area, is more common in individuals with dark skin (165), which are more likely to carry a fully functional wild-type form of the MC1R gene, compared to individuals with lighter skin

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