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This mechanism makes it especially attractive for patients with obesity complicated by metabolic disorders such as type 2 diabetes and metabolic dysfunctionassociated fatty liver disease (MAFLD)

Two anti-obesity agents, lorcaserin and the combination of phentermine and topiramate, have been shown to improve glycemic control in obese individuals with type 2 diabetes

In commercial plans and employer groups, adoption is accelerating: a 2025 Health Affairs/KFF survey found that 43% of firms with 5,000+ employees now cover GLP-1s for weight loss, up from 28% in 2024 ( [26] ), and 57% of employers overall cover GLP-1s for weight loss according to WTW survey data ( [27] )