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A notable limitation of these agents is the need for continuous treatment, as discontinuation has been associated with rebound weight gain ( The addition of GLP-1 RAs to insulin therapy may allow for improved glycaemic control and, in selected cases, potential de-escalation or discontinuation of insulin

For some, side effects are severeespecially at the higher doses needed to achieve their health goals

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Diamanti-Kandarakis E, Dunaif A (2012) Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications