LY3298176 was characterised in vitro, using signaling and functional assays in cell lines expressing recombinant or endogenous incretin receptors, and in vivo using body weight, food intake, insulin secretion and glycemic profiles in mice
This unique ability to modulate hunger signals is crucial, as it helps individuals make healthier food choices and adhere to calorie restrictions more easily.
This theory implies that MFs can act as cellular messengers, eliciting physiological responses such as changes in cell survival, proliferation, apoptosis, differentiation, gene expression, protein synthesis, enzymatic activity, and ion homeostasis (Ouyang, 2019
Look at the incretin/GLP-1 story as a mechanism class, not as isolated products: Ozempic reached $1B in 3 years