Acute treatment of diet-induced obese mice with labelled semaglutide has been shown to allow the drug to access circumventricular organs that lack a substantial blood brain barrier, including the area postrema (AP), median eminence (ME), vascular organ of the lamina terminalis (OV), and subfornical organ (SFO) (33)
However, GLP-1 RA therapy has gastrointestinal side effects, including nausea, increases the risk of undernutrition, and can decrease lean body mass
Krajnc N, Itariu B, Macher S, et al
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