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In a multicellular organism, TLs are highly heterogeneous across different tissues and cell types depending, at least partly, on the tissue-specific proliferation rate, but they generally tend to decrease with age in all proliferating tissues (Demanelis et al., The size of critically short (uncapped) telomeres may be stabilized by telomerase, a reverse transcriptase enzyme that can elongate chromosome ends de novo

Interestingly, the commensal microbiota in the gut has been shown to impact locomotor behavior in different animal models to various degrees 13,14,15,16

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Staron, G