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Factors favoring earlier intervention include strong family history of diabetes, multiple metabolic risk factors, prior gestational diabetes, or failed lifestyle modification attempts

"Comparative Bioavailability and Utilization of Particular Forms of B12 Supplements With Potential to Mitigate B12-related Genetic Polymorphisms"

| Weeks | Dose | Purpose | |---|---|---| | 1 to 4 | 0.25 mg once weekly | Tolerability induction | | 5 to 8 | 0.5 mg once weekly | Minimum effective therapeutic dose | | 9 to 12 (optional) | 1.0 mg once weekly | Enhanced glycemic control | | 13 to 16 (optional) | 1.7 mg once weekly | Bridge to maximum dose | | 17+ (optional) | 2.0 mg once weekly | Maximum approved dose for T2D | Dose advancement is not mandatory at every step