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In vitro effects of glutamate and N-methyl-D-aspartate receptor (NMDAR) antagonism on human tendon derived cells

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IL10, which codes for the anti-inflammatory cytokine interleukin-10 (IL-10), is down-regulated 2.2-fold following PQ-treatment (Table 2), suggesting that the cell may be actively repressing anti-inflammatory mediators in favor of proinflammatory mediators (e.g., IL-8)