may 22 semaglutide Compounded Safety: What You Should Know NIH locates semaglutide's brain handle:

Empty calories and phantom fullness: a randomized trial studying the relative effects of energy density and viscosity on gastric emptying determined by MRI and satiety

As a very simple way of looking at it, when your body is constantly being bombarded with glucose and insulin as a result of poor diet and lifestyle factors, your body eventually becomes desensitized to insulin, which starts you down the path to insulin resistance

Indeed, sarcopenia has been associated with impaired mobility, increased frailty, higher hospitalization rates and excess mortality [4]

Severe, life-threatening, generalized allergy, including anaphylaxis, can occur with insulins, including LANTUS [see Adverse Reactions (6.1)]