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They also help soothe red, irritated skin associated with acne

Glutathione works as a potent antioxidant that helps reduce pigmentation and supports a brighter-looking complexion, while Niacinamide helps refine skin texture, minimize dullness, and strengthen the skin barrier

Proc Natl Acad Sci USA 93 : 83188323 Werner H, Le Roith D (2000) New concepts in regulation and function of the insulin-like growth factors: implications for understanding normal growth and neoplasia

Additionally, gastrointestinal side effectsnausea, constipation, or mild diarrheacan increase insensible fluid loss or discourage drinking when mild stomach discomfort is present