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This could be attributed to the parallel effect of DHODH and GPX4 mito on inhibiting ferroptosis

Salamanca N, Moreno O, Girldez I, Morales E, de la Rosa I, Herrera M

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Although previous studies have used nano-fluorescent probes to detect the cellular delivery efficiency of oligonucleotide molecules, 403,457,575 more pharmacokinetic data on biodistribution, immune compatibility, and toxicity are needed for clinical translation and practical therapeutic application of these systems