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The effects of pregabalin and placebo were similar after the 3-week treatment, but mirogabalin at a dose of 15, 20, or 30 mg/day was significantly better than placebo in inducing a change in ADP score (0.94, 0.88, and 1.01, respectively) [37]

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Sustained depletion of NRF2 upon Gclc deletion induces a sex-dependent requirement for NRF2 to maintain liver homeostasis and animal survival Liver-specific deletion of Gclc impaired the expression of lipogenic enzymes and lowered circulating triglyceride levels