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The curve flattens

However, some sex-specific considerations are worth noting: Testosterone and hormonal health: Significant weight loss achieved through these agents may lead to improvements in testosterone levels in men with obesity-related hypogonadism

Diabetologia 14 (2), 7587

In AP, however, disruption of inter-organellar communication converts this coordinated network into a feed-forward system that intensifies mitochondrial dysfunction and acinar-cell injury ( Figure 2 )