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In vitro characterization is classically done on cloned human receptors expressed in cell lines (HEK293, CHO) via cAMP measurements (ELISA, FRET) or beta-arrestin recruitment (BRET, NanoBiT)

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The article puts acute pancreatitis at 0.1 to 0.3 percent in trials, listing it among rare but serious events alongside gallbladder issues and thyroid C-cell tumors observed in animal models