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Continuation vs Discontinuation of Renin-Angiotensin System Inhibitors Before Major Noncardiac Surgery: The Stop-or-Not Randomized Clinical Trial

Most studies show no major change in clearance, but patients with kidney or liver problems should be monitored closely to avoid the risk of any side effects

Efficacy and safety of tirzepatide monotherapy compared with dulaglutide in Japanese patients with type 2 diabetes (SURPASS J-mono): a double-blind, multicentre, randomised, phase 3 trial

Significant weight loss typically begins within the first month, with clinical studies showing average weight loss of 15-20% over 6-12 months with consistent treatment and lifestyle modifications