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Common (Usually Transient) Side Effects Water retention or puffiness Carpal tunnel-like symptoms Joint stiffness (often temporary) Mild insulin resistance if overdosed How We Monitor Baseline and follow-up IGF-1 levels Body composition changes Symptom tracking and dose titration Our goal is to maintain IGF-1 in the high-normal physiologic range , not to create supraphysiologic levels

Cardiovascular outcomes have been studied in diabetes programs, but long-term cardiovascular and renal effects need continued follow-up through registries and post-marketing safety data

Dermatol 134 (8), 22212230

Use an ampoule opener to safely open before use as they tricky to open