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However, more recent evidence has clarified that IgG13 (and IgG1 in particular) can also counteract the inflammatory allergic response to antigens, in part through FcRII signaling in some cell types

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Maebashi M, Kawamura N, Sato M, Imamura A & Yoshinaga K (1978): Lipid-lowering effect of carnitine in patients with type-IV hyperlipoproteinaemia

So, while it's important to note the rise in TMAO associated with high doses, carnitine supplementation may also offer cardioprotective properties for people with certain conditions