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Key secondary endpoints included number of participants achieving 10%, 15%, 20% and 25% weight loss, respectively

The results of the study say that spironolactone reduces the symptoms of hirsutism by about 40% and shows efficacy in 50% of treated individuals when used as monotherapy (132)

The duration effect suggests GHK-Cu induces cumulative structural changes in dermal architecture where longer treatment allows more complete remodeling supporting ongoing enhanced function without continuous peptide presence