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The vascular endothelial dysfunction is a critical step of atherogenesis which is usually characterized by endothelium-dependent vasodilatation and vasoconstriction imbalance and the disturbed balance of antithrombotic and prothrombotic factors 4

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While early Phase 2 data show a promising efficacy profile, the full side effect picture is still emerging

Retatrutide is only accessible via approved clinical trials, and tesamorelin is not licensed for any indication by the MHRA