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Leptin is a hormone involved in regulating energy balance and appetite, which could imply that increased food intake may contribute to the observed weight gain in peptide-exposed models, which then may increase leptin levels and subdue appetite

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These dose-dependent effects include reductions in: inflammatory pathway activations proinflammatory cytokine and collagen degradation enzyme expressions mitochondrial dysfunction oxidative stress According to the above review, all three studies highlighted that GLP-1 analogs may work to treat RA by inhibiting the nuclear factor kappa-light-chain-enhancer of activated B cells pathway, which can improve immune responses

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