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Choi et al., 2013

Taube and Schwartzkroin (1987) report that, out of 12 basket cells tested, three expressed potentiation, three expressed depression, and in the remaining six cells, no change or a small increase of EPSP amplitude was observed

For that reason, many experts classify tirzepatide as a dual GIP and GLP-1 receptor agonist rather than simply a GLP-1 medication

Adjustments in Diabetes Treatment to Avoid Hypoglycemia For patients with diabetes, particularly those on medications for diabetes management, the use of Wegovy requires careful monitoring and possible adjustments