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[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Ksters-Vandevelde HV, van Engen-van Grunsven IA, Ksters B, van Dijk MR, Groenen PJ, Wesseling P, et al

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According to the National Academies of Sciences, Engineering, and Medicine (NAP), a safe highest level is called the tolerable upper intake level. Assessment of what amount is too much is based on animal and human studies, published evidence of adverse events, and professional agreement based on a committee of experts