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Conversely, in glioblastoma, inhibition of HSP60 increases mitochondrial ROS generation, triggering AMPK activation and suppressing mTORC1-mediated phosphorylation of S6K and 4EBP1

Thyroid function tests (TSH, free T4) should be checked at baseline, 6-8 weeks after achieving maintenance dose of the weight loss medication, and every 3-6 months during active weight loss to ensure appropriate thyroid hormone replacement

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