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Its presence may reshape treatment algorithms, patient engagement, and the future of type 2 diabetes care

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This Ca 2+ influx, along with elevated ATP, results in exocytosis of the plasma membrane docked immediate release pool (IRP) of insulin granules, a sub-pool of the readily releasable pool (RRP) which contains ~15% of available insulin granules ( st phase stimulus-secretion coupling, since it is the products of glucose catabolism that ultimately drive insulin exocytosis

The picture remains incomplete, however, when assessing the mechanism by which this is achieved and if these cardiovascular effects can be generalized for the entire class of drugs