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Perspective on the Rx Pipeline: Diabetes and GLP-1 Agonists Situation Summary Initial therapy for individuals with T2DM who are at high risk for CVD, heart failure (HF) and/or chronic kidney disease is metformin and a glucagon-like peptide 1 (GLP-1) or sodium glucose transporter ligand 2 (SGLT-2)

In vitro studies demonstrated that AOD-9604 can directly stimulate lipolysis in isolated human adipocytes, though the potency was lower than native GH or synthetic lipolytic agents like epinephrine or isoproterenol

A: GLP-1 drugs typically dont replace current medications