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After being on ketogenic diet for 4 to 7 months, both patients, a 42-year-old male (patient 1) and a 35-year-old female (patient 2), demonstrated marked increase in absolute GSH levels in both gray matter (0.12 to 1.40 and 0.10 to 0.70 international unit [IU]) and white matter (0.65 to 1.50 and 0.80 to 2.00 IU), as well as at least 50% improvement in seizure duration and frequency (Table 1)

Integrated colon microbiome and metabolomics to elucidate the antidepressant mechanisms of the radix bupleuri-radix paeoniae alba herb pair