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& Laway, B

Disruption of these pathways due to IR impairs synaptic plasticity, promotes neurodegeneration, and increases the risk of AD

Clinical research validates this targeted approach

Indeed, GSH, Trx, Grx, Prx (together with the enzymes catalyzing their reduction), and the enzymatic antioxidant defense, as a whole, concur to modulate either ROS concentration, or the availability of cellular thiols, thus regulating the function of a large number of proteins implicated in the induction and/or execution of redox-sensitive pathways