Employers who provide insurance to their employees work with pharmacy benefit managers to manage prescription drug benefits, and in doing so they put in place a dizzying array of limitations to try to control costs
Patent expiries like this clearly demonstrate how innovation and generic medicines together can enhance healthcare accessibility in developing countries
Pickarts scale categorizes strengths: 3ppm (mild, sensitive), 10ppm (general anti-aging), 28ppm+ (intensive repair)
The most well-known examples, apart from pioglitazone, are fenofibrate, pemafibrate, seladelpar, elafibranor and lanifibranor, which have been studied in various trials regarding their effect on liver inflammation and fibrosis, without particular success, with the exception of lanifibranor, a pan-PPAR agonist, which was shown in a phase 2b RCT (NATIVE-NCT03008070) to improve ballooning and inflammation, without worsening of fibrosis