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Spermatogenesis is a highly complex and precisely regulated physiological process governed by the hypothalamic-pituitary-testicular (HPT) axis and involving mechanisms such as redox balance, endocrine signaling, microcirculatory stability, and epigenetic regulation

Depletion and Disease 5

In particular, GSH participates in the process of methylglyoxal (a toxic by-product of metabolism) detoxification, a two-step enzymatic process mediated by glyoxalase enzymes

Besides, prior study has established that the activation of PPAR- can reduce the production of inflammatory factors provoked by AGEs across diverse cell categories [57]