There are three types of animal models: homologous (identical to humans), isomorphic (resembling a human disorder) and predictive (allowing the prediction of human disease and treatment) (Xu et al., 2021)
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This work was supported by research grants from the National Heart, Lung, and Blood Institute (R01HL126901 and R01HL149302 to MA, and R01HL174066 to MA and EA)
SGLT-2 Inhibitors and BBB Physicochemical properties, including molecular weight, pKa, LogP oct , HBA and HBD, are critical parameters related to the ability of drugs to cross the BBB