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Here is the honest state of the data: Obesity (Phase 2, randomized controlled trial): the landmark New England Journal of Medicine Phase 2 trial in obesity established both the once-weekly dosing and the escalation approach, and reported the largest average weight reductions seen for a once-weekly agent with the caveat that the reduction had not fully plateaued at 48 weeks

"Despite people with the PAM variant having higher circulating levels of GLP-1, we saw no evidence of higher biological activity," says endocrinologist Anna Gloyn, from Stanford University

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