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In summary, the potential mechanism by which diabetes contributes to neurodegeneration in AD and PD may involve the accumulation of AGE and cellular IR

Oxidized forms of metals (Fe 3+ , Cu 2+ ) are quickly restored in the cytosolic environment, fueling the vicious circle

Mechanism Comparison in Skin Cell Culture GHK-Cu Mechanisms in Skin Research GHK-Cu's activity in skin cell culture operates through multiple simultaneous mechanisms: Copper-dependent enzyme activation: GHK-Cu delivers bioavailable copper to copper-dependent enzymes including lysyl oxidase (collagen and elastin cross-linking) and superoxide dismutase (antioxidant defense)

FIGURE 3 3.2 Sensitivity analyses To ensure the reliability of our findings, we conducted several sensitivity analyses