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History of Pancreatitis, Gastroparesis, and Gastrointestinal Surgery Acute or chronic pancreatitisinflammation of the pancreasis a relative contraindication to GLP-1 use

GLP-1R action on neuroprotection GLP-1R analogs have neuroprotective and anti-inflammatory properties, which may be contributing the beneficial effects on energy metabolism (reviewed in Holscher, 2014)

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