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NHS prescribing follows NICE Technology Appraisals (TA875 for Wegovy and TA664 for Saxenda) and typically occurs within specialist weight management services

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Some patients are naturally less responsive to incretin-based therapies, though this represents a minority of cases

The investigators were granted access to the databases used to create the study population and performed several quality checks (consistency assessments, range and logic checks) before the linkage of the databases using a pseudonymised single identification number