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11 In islet alpha-cells, prohormone convertase 2 modifies proglucagon to produce glucagon, which is formed by the removal of aa residues adjacent to 33 and 61 of proglucagon

Although GLP-1 increased cytokine production in resting iNKT cells, both GLP-1 and liraglutide inhibited cytokine secretion following treatment with phorbol myristate acetate/ionomycin, or in iNKT cells activated by co-culture with glycolipid-treated CD1d-transfected C1R cells, actions blocked by the GLP-1R antagonist exendin (939)

In order to overcome the short half-life of GLP-1 and improve stability, researchers at Novo Nordisk used genetic engineering techniques to modify the amino acid sequence of GLP-1 to produce a more stable and long-lasting analogue, insulin-like Peptide-1 receptor agonist (GLP-1 RA)