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Annals NYAS

Experimental models have demonstrated that phenytoin and carbamazepine activate the nuclear receptors PXR and constitutive androstane receptor (CAR), inducing CYP3A4-mediated VD hydroxylation and CYP24A1 overexpression through genomic and post-translational mechanisms [152]

Mech Ageing Dev 2001;122:4168

Additionally, as the closely interrelated increased pressure in the three body cavities was rapidly transmitted through the venous system [23] (and thereby, the venous system can be seen as a therapy target [14,15,16,17,18,19,20,21,22,23]), the brain swelling and lesions and increased pressure in the superior sagittal sinus may induce a comparable deadly syndrome [20]