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4 However, GLP-1 receptor agonists and gut-derived GLP-1 do not cross the bloodbrain barrier and cannot access GLP-1 receptors in the brain parenchyma, which can only be accessed by brain (pre-proglucagon neuron) derived GLP-1

It is estimated that a typical diet contains 3 to 6 grams per day

The core PA criteria T2D diagnosis plus metformin step-therapy are the same

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