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Significant weight reduction can lead to decreased skin elasticity, increased skin laxity, dryness, and subjective changes in skin texture

The titration phase typically lasts 48 weeks, moving through 0.25 mg, 0.5 mg, 1.0 mg, 1.7 mg, and finally 2.4 mg

Instead of relying primarily on historical relationships, many sponsors are exploring more data-driven approaches to site selection, including: regional disease heatmaps investigator performance analytics patient population modeling AI-assisted feasibility analysis These approaches aim to answer a fundamental question: Which sites can actually recruit the patients required for modern metabolic trials

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