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[7] A boxed warning in the US prescribing information cautions that medullary thyroid cancers have been observed in rats treated with liraglutide, but it is "unknown whether liraglutide causes thyroid C-cell tumors, including medullary thyroid carcinoma, in humans, as relevance to humans of such tumors in rodents has not been determined." [7] Thyroid cancer [edit] At exposures eight times greater than those used in humans, liraglutide caused a statistically significant increase in thyroid tumors in rats

N -phenoxyacetamides with electron-rich or electron-deficient substituents reacted smoothly to give the desired para -CH amination products ( 2ak ) in moderate to excellent yields (6292%)