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Hara et al reported two LBD mutations, W741L and W741C, in LNCaP cells that appeared during bicalutamide treatment and caused the receptor to be activated by bicalutamide 172

DOI: 10.1371/journal.pone.0171352

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Given the effects of GLP-1 receptor agonists on body weight and fat, the question arises of whether a reduction in kidney-specific fat depots could contribute to the kidney-protective effects of GLP-1 receptor agonist treatment