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The location of the p -hydroxylation and -hydroxylation reactions is important in species where aromatic hydroxylation of amphetamine is the predominant pathway of metabolism

Further, mechanistic studies further demonstrate that MSR1 (SR-A) can physically synergize with Toll-like receptor 4 to amplify NF-kB signaling and pro-inflammatory cytokine release, providing a potential molecular bridge to the cytokine storm characteristic of MAS leading to systemic organ damage (332, 333)

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