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clinicians should clearly communicate this limitation

Instead, focus on comprehensive plans that combine sustainable diet changes, activity, behavior support, and, when appropriate, medical options that have robust human trial evidence

A meta-analysis of studies using NAC to increase athletic performance found that there were more side effects (none severe) at 20g/day.[ref] High doses of NAC are used in hospitals by IV for reversing acetaminophen toxicity

Wearable sensors and smartphones now enable real-time symptom tracking, and ML algorithms can stratify patients for adaptive trial designs and biomarker discovery (Burchill et al., 2024